| Name | Location | Status | Design | Year Built | Year Lost | Span Length | Total Length |
|---|
| Bill Emerson Memorial Bridge | MO 34/IL 146 over Mississippi River | Open to four-lane traffic | Cable-stayed | 2003 | -- | 1150.0 ft. | 3956.2 ft. |
| Cache Channel Illinois Central Bridge | Illinois Central Railroad over Cache River Diversion Channel | Still standing, but rails removed | Pony plate girder | -- | -- | -- | -- |
| Cache Channel Missouri Pacific Bridge | Missouri Pacific Railroad over Cache River Diversion Channel | Several concrete piers remain | Pony plate girder | -- | -- | -- | -- |
| Cairo I-57 Bridge | Interstate 57 over Mississippi River | Open to four lanes of traffic | Steel through arch | 1978 | -- | 820.7 ft. | 4088.8 ft. |
| Cairo Mississippi River Bridge | US 60/62 over Mississippi River | Open to two-lane traffic with a 40 ton weight limit | Cantilevered through truss | 1929 | -- | 700.9 ft. | 5175.5 ft. |
| Cairo Ohio River Bridge | US 51/60 over Ohio River | Open to two-lane traffic | Cantilevered through truss | 1937 | -- | 800.0 ft. | 5863.7 ft. |
| Cairo Railroad Bridge | Illinois Central Railroad over Ohio River | Open to railroad traffic | Warren through truss | 1952 | -- | -- | -- |
| Cape Girardeau Bridge | MO 34 over Mississippi River | Replaced by Bill Emerson Memorial Bridge and closed to all traffic on December 13, 2003; main spans demolished on September 9, 2004 | Cantilevered through truss | 1928 | 2004 | 671.0 ft. | 4744.3 ft. |
| Drainage Ditch IL 3 Bridge | IL 3 over Drainage Ditch | Open to traffic | Steel stringer | 1948 | -- | 45.9 ft. | 122.0 ft. |
| Fayville Road Bridge | Fayville Road over Orchard Creek | No longer standing, but north abutment remains underneath the replacement bridge | Unknown | -- | -- | -- | -- |
| First Cairo Railroad Bridge | Illinois Central Railroad over Ohio River | Replaced by the current bridge, but reusing many of the piers | Whipple through truss | 1889 | 1949 | 518.5 ft. | 20461.0 ft. |
| Gale Bridge | Old IL 3 over Sexton Creek | Open to two-lane traffic with a 36 ton weight limit | Pratt through truss | 1933 | -- | 172.2 ft. | 336.9 ft. |
| Miller Creek Bridge | Old IL 3 over Miller Creek | Open to two-lane traffic | Pratt pony truss | 1933 | -- | 81.7 ft. | 147.9 ft. |
| Rock Spring Hollow Trestle | Missouri Pacific Railroad over Orchard Creek/Rock Spring Hollow | Several concrete footings remain | Unknown | -- | -- | -- | -- |
| Thebes Bridge | Thebes Bridge Terminal Railroad over Mississippi River | Open to railroad traffic on two tracks | Cantilevered through truss | 1905 | -- | 671.0 ft. | 2750.0 ft. |